However, the second is the most common and involves downloading an auto clicker. All you have to do is enable auto-click if your PC has an inbuilt auto-click setting. The first is the least common way and doesn’t involve you downloading an auto-clicker. Generally, you can make your computer mouse perform an auto click in two main ways. How To Make a Mouse Click Automatically on a Mac PC.How To Make a Mouse Click Automatically on a Windows PC.